Acceptable but should be monitored

Finished thinking

Bowden CL, Janicak PG, Orsulak P, et al. Relation of Serum Valproate Concentration to Response in Mania. The American Journal of Psychiatry. 1996;153(6):765-70. doi:10.1176/ajp.153.6.765. PMID: 8633687 is the citation by Dr. Charles Bowden from the mid-1990s specifically addressing divalproex in bipolar disorder. [1]
This study demonstrated that acutely manic patients treated with divalproex who achieved serum valproate levels between 45 and 100125 micrograms/mL were more likely to have efficacious and well-tolerated responses, while adverse effects were disproportionately associated with levels ≥125 micrograms/mL.

1.
Relation of Serum Valproate Concentration to Response in Mania.
Bowden CL, Janicak PG, Orsulak P, et al.
The American Journal of Psychiatry. 1996;153(6):765-70. doi:10.1176/ajp.153.6.765.

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https://link.springer.com/content/pdf/10.1186/s13054-024-05034-7.pdf

s13054-024-05034-7.pdf

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