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Joseph (Joe) E. Thornton, M.D., DFAPA
Sublingual dexmedetomidine for treatment of agitation in bipolar disorder.
Randomized Placebo controlled trial reported in JAMA demonstrated effectiveness over placebo at 2 hours. The medication was well tolerated.
Not clear if the clinical effect is sufficient.
Preskorn SH, Zeller S, Citrome L, et al. Effect of Sublingual Dexmedetomidine vs Placebo on Acute Agitation Associated With Bipolar Disorder: A Randomized Clinical Trial. JAMA. 2022;327(8):727–736. doi:10.1001/jama.2022.0799
Joseph (Joe) E. Thornton, M.D., DFAPA
Alzheimers disease like signaling in the brains of COVID-19 patients
Reiken et al from Columbia University extrapolate esoteric data from the neurochemistry of older patients with Alzheimer disease and finds similarities in this study neurocognitively impaired patients who died from COVID-19.
The main argument I find to dispel that this is simply a finding from 2 separate but very common comorbid conditions, is that the patients with COVID-19 had the pathological findings in the cerebellum which is not a location impacted by Alzheimer’s disease. They then promote their findings by stating IF this finding is true (increased activity on the ryanodine receptor) then MAYBE there is a POTENTIAL target for treatment.
Figure 4 might be of interest
JT
Joseph (Joe) E. Thornton, M.D., DFAPA
Reiken – Alzheimer s$B!>(Blike signaling in brains of COVID$B!>(B19 patients.pdf
Antidepressants – Nemeroff overview
Joseph (Joe) E. Thornton, M.D., DFAPA
Nemeroff C 2021treatment of Major Depression?Psychiatric News.pdf
henssler_2022_oi_antidepressant combo jamapsychiatry_.pdf
Breaking News: U.S. deaths during pregnancy or shortly after spiked in the pandemic’s first year, especia lly among Black and Hispanic women, a report said.
Maternal deaths increased from 740 in 2020 to 821 in 2021
10 most common sentinel events of 2021: Joint Commission
Comorbidity of Bipolar disorder and Migraines
Mahmood T, Silverstone T. Twin concordance for bipolar disorder and migraines. Am J Psychiatry. Dec 2000;157(12):2057.
Fornaro M, Stubbs B. A meta-analysis investigating the prevalence and moderators of migraines among people with bipolar disorder. J Affect Disord. Jun 01 2015;178:88-97.
abstract by Fornaro …..
Joseph (Joe) E. Thornton, M.D., DFAPA
UBC Neuroanatomy
Associations Between Neuropsychiatric Symptoms and Neuropathological Diagnoses of Alzheimer Disease and Related Dementias | Dementia and Cognitive Impairment | JAMA Psychiatry | JAMA Network
UT Health San Antonio, University Health perform region’s first surgery for Alzheimer’s disease – UT Hea lth San Antonio
Joseph (Joe) E. Thornton, M.D., DFAPA
Adjunct Clinical Associate Professor, Psychiatry
University of Florida College of Medicine
joethornton@ufl.edu
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