Tweet by Brain on Twitter tau accumulation in AD

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Brain
⁦‪@Brain1878‬⁩
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Insel et al. examine the regional accumulation of tau in cognitively unimpaired older adults, and show that the inferior temporal cortex may be the critical region for rapid tau accumulation in preclinical Alzheimer’s disease. bit.ly/3QY0g0f pic.twitter.com/I68WhbPNR7
8/23/22, 4:09 AM

Joseph Thornton

Follow up on metformin fo COVID

Official finding is none of the 3 drugs were effective for COVID

JT

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 | NEJM

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 | NEJM
Abstract Background Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronaviru…
http://www.nejm.org

secondary analysis showed an aOR for an ED visit, hospitalization, or death of 0.58 (95% CI, 0.35 to 0.94) with metformin, 1.39 (95% CI, 0.72 to 2.69) with ivermectin, and 1.17 (95% CI, 0.57 to 2.40) with fluvoxamine. The aOR for hospitalization or death was 0.47 (95% CI, 0.20 to 1.11) with metformin, 0.73 (95% CI, 0.19 to 2.77) with ivermectin, and 1.11 (95% CI, 0.33 to 3.76) with fluvoxamine. The fluvoxamine arm was stopped early due to futility. The secondary analysis isn’t conclusive because the group couldn’t test its significance.

Joseph (Joe) E. Thornton, M.D., DFAPA
Clinical Associate Professor, Psychiatry
University of Florida College of Medicine
joethornton@ufl.edu

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Tweet by Oren Gottfried, MD functional neurological disorder

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Oren Gottfried, MD
⁦‪@OGdukeneurosurg‬⁩
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Please see a current and accurate review of Recognising Functional Neurological Disorders from ⁦‪@bmj_latest‬⁩. Thank you for helping me ⁦‪@jonstoneneuro‬⁩ ⁦‪@FndPortal‬⁩ ⁦‪@FNDSociety‬⁩. pic.twitter.com/Ow4z3hwlpH
8/22/22, 10:30 AM

Joseph Thornton

Felitti ACE article we discussed,, plus TED talk by Dr Nadine Burke Harris

Attached
Felitti VJ. Origins of the ACE Study. Am J Prev Med. 2019 Jun;56(6):787-789.

A short 3-page article describing the history of one of the most influential public health findings of the past 25 years

Notice not just resistance, but hostility, to its findings that persist to this day.

On consults, I used to refer the students to a brief TED talk by Nadine Burke Harris on applications in child health in 2015.
Nadine Burke Harris: How childhood trauma affects health across a lifetime | TED Talk

How childhood trauma affects health across a lifetime – TED
Childhood trauma isn’t something you just get over as you grow up. Pediatrician Nadine Burke Harris explains that the repeated stress of abuse, neglect and parents struggling with mental health or substance abuse issues has real, tangible effects on the development of the brain. This unfolds across a lifetime, to the point where those who’ve experienced high levels of trauma are at triple …
http://www.ted.com

later on, from 2019 – 2021 she was the Surgeon General fo the Stae of CAlifornina.
Nadine Burke Harris – Wikipedia

Nadine Burke Harris – Wikipedia
Nadine Burke Harris (born 1975) is a Canadian-American pediatrician who has been the Surgeon General of California since 2019; she is the first person appointed to that position. She is known for linking adverse childhood experiences and toxic stress with harmful effects to health later in life. Hailed as a pioneer in the treatment of toxic stress, she is an advisory council member for the …
en.wikipedia.org

JT

Joseph (Joe) E. Thornton, M.D., DFAPA
Clinical Associate Professor, Psychiatry
University of Florida College of Medicine
joethornton@ufl.edu

Felitti VJ 2019 Origins of ACE study .pdf