Post by Chris Palmer, MD on X. ACE. Alzheimer’s

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Chris Palmer, MD
⁦‪@ChrisPalmerMD‬⁩
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Adverse childhood experiences increase risk for Alzheimer’s disease.

Rare genetic variants (APP and PS1) also increase risk.

This study of mice suggests they “share pathogenic pathways involving synaptic mitochondrial dysfunction and lipid metabolism.”
alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
1/8/24, 7:38 AM

Joseph Thornton

Post by Michael Mindrum registry less suicide ideation w semaglutide

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Michael Mindrum ☸️
⁦‪@MichaelMindrum‬⁩
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📣New study: semaglutide compared with non-GLP1R agonist anti-obesity medications associated with lower risk for incident (HR = 0.27) and recurrent (HR = 0.44) suicidal ideation, consistent across sex, age and ethnicity stratification. nature.com/articles/s4159… H/t ⁦‪@ChrisPalmerMD‬⁩
1/5/24, 1:45 PM

Joseph Thornton