Acceptable but should be monitored
Finished thinking
Bowden CL, Janicak PG, Orsulak P, et al. Relation of Serum Valproate Concentration to Response in Mania. The American Journal of Psychiatry. 1996;153(6):765-70. doi:10.1176/ajp.153.6.765. PMID: 8633687 is the citation by Dr. Charles Bowden from the mid-1990s specifically addressing divalproex in bipolar disorder. [1]
This study demonstrated that acutely manic patients treated with divalproex who achieved serum valproate levels between 45 and 100125 micrograms/mL were more likely to have efficacious and well-tolerated responses, while adverse effects were disproportionately associated with levels ≥125 micrograms/mL.
1.
Relation of Serum Valproate Concentration to Response in Mania.
Bowden CL, Janicak PG, Orsulak P, et al.
The American Journal of Psychiatry. 1996;153(6):765-70. doi:10.1176/ajp.153.6.765.
Gator Psychiatry 